Science

ORCID: 0000-0002-5831-5158

Profile on pure.au.dk

Preclinical

Psilocybin

Could psilocybin (a mushroom psychedelic) be used for treating depression? And how does it work?

As a pregraduate research year student, this is what worked with at Translational Neuropsychiatry Unit (TNU) in Aarhus, investigating the antidepressive effect and molecular mechanisms of psilocybin in an animal model of depression.

We recently published this article in Acta Neuropsychiatrica, showing that psilocybin lacks an antidepressant-like effect in the Flinders Sensitive Line, a genetic rat model of depression. This does not disprove the putative effects seen in human trials, but rather suggests that another animal model should be used when working with psilocybin.

Systematic reviews of preclinical research

With post.doc Alexandra Bannach-Brown, I am conducting systematic reviews  to optimize evidence synthesis in preclinical research.

Epidemiological

ph.d.stud. Maria Speed, assistant professor Doug Speed, and professor Søren D. Østergaard, and I recently published a paper in Translational Psychiatry on the causal effect of fat mass on depression using Mendelian Randomization analysis.

 

If you have any inquiries, please write me at oskar.jefsen@clin.au.dk